Thiotepa fachinformation
WebNov 1, 2024 · The recommended dose of Thiotepa for injection for treatment of adenocarcinoma of the breast or ovary is 0.3 to 0.4 mg/kg intravenously. Doses should be …
Thiotepa fachinformation
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http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Thiotepa_monograph_1June2013_formatted.pdf WebThiotepa is approved to treat: Bladder cancer. Breast cancer. Malignant pleural effusion, malignant pericardial effusion, and malignant peritoneal effusion. Ovarian cancer. Thiotepa is also being studied in the treatment of other types of cancer and as part of a regimen to prepare patients for bone marrow and stem cell transplants.
WebFeb 17, 2024 · Thiotepa and TEPA exposure increased 1.5-fold and 2.6-fold, respectively, following administration of multiple doses of 120 mg/m 2 /day in a patient with moderate renal impairment (CrCl 38 mL/minute), compared to patients with normal renal function. Special Populations: Hepatic Function Impairment. WebSep 6, 2024 · Thiotepa may be given by rapid intravenous administration in doses of 0.3 to 0.4 mg/kg. Doses should be given at 1 to 4 week intervals. The dosage recommended is …
WebWhat is thiotepa? Thiotepa is a chemotherapy medicine used in combination with other drugs for the treatment of certain types of cancer in children. It is also used before bone marrow transplantation or high dose therapy with stem cell rescue to help treat certain types of cancer and metabolic conditions. Webprecautions should be followed when handling thiotepa; if skin contact occurs, wash the area thoroughly with soap and water; if mucous membrane contact occurs, flush thoroughly with water. 2. Carcinogenicity: Thiotepa is carcinogenic. 2. Mutagenicity: Mutagenic in Ames test and mammalian in vitro mutation test. 2 Thiotepa is clastogenic in ...
WebApr 2, 2024 · Thiotepa is a cytotoxic agent of the polyfunctional type, related chemically and pharmacologically to nitrogen mustard. The radiomimetic action of thiotepa is believed to …
WebSep 21, 2024 · Thiotepa side effects. Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.. Thiotepa may cause serious side effects. Call your doctor at once if you have: sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad … burlington uniontown paWebThiotepa Riemser 100 mg powder for concentrate for solution for infusion 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Thiotepa Riemser 15 mg powder for concentrate for solution for infusion One vial of powder contains 15 mg thiotepa. After reconstitution with 1.5 mL of water for injections, each mL of solution contains 10 mg thiotepa burlington union newsWebthiotepa is rapid and is followed by fast elimina-tion from the plasma compartment, with a half-life of 1–3 hours. Triethylenephosphoramide (TEPA), a metabolite of thiotepa, is … halsspecialistWebThiotepa (N,N′,N″-triethylenethiophosphoramide, MW 189) is an older chemotherapeutic anticancer agent that acts by alkylating DNA and is prescribed for treating solid tumors and various leukemias often at high doses and in combination with other anticancer agents. Mass spectrometric methods were developed for characterizing the structure of thiotepa … burlington union maWebthat thiotepa is metabolized by CYP3A4 and CYP2B6. The major active metabolite of thioetpa is TEPA (triethylenephosphoramide) per thiotepa labeling. Elimination: The mean elimination half-life was 1.7 hours (thiotepa) and 4 hours (TEPA) in pediatric population, and from 1.4 hours to 3.7 hours for thiotepa and from 4.9 hours to 17.6 burlington union paperWebThiotepa (TEPADINA ®) is used to treat some blood cancers and several other types of cancer. It is given before a stem cell transplant or bone marrow transplant. It is best to read this information with our general information about chemotherapy and the type of cancer you have. Your doctor will talk to you about this treatment and its possible ... burlington union njWebFeb 13, 2024 · Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours. The objective was to assess the incidence of NAE related to high-dose thiotepa and to identify potential contributing factors that could exacerbate the occurrence of this neurotoxicity. From May … burlington union station