Improving protein succinylation sites
WebThe potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da), it is expected to lead to more significant changes in protein structure and … WebMar 31, 2024 · Barley (Hordeum vulgare L.)—a major cereal crop—has low Pi demand, which is a distinct advantage for studying the tolerance mechanisms of phosphorus deficiency. We surveyed dynamic protein succinylation events in barley roots in response to and recovery from Pi starvation by firstly evaluating the impact of Pi starvation in a Pi-tolerant (GN121) …
Improving protein succinylation sites
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WebAug 15, 2024 · In 2013, through the research of Park et al., 2565 protein succinylation sites were identified in 779 proteins, and their experimental results showed that the enzymes produced by lysine succinylation had potential effects on the metabolic function of mitochondria, such as the degradation of amino acids, the circulation of tricarboxylic … WebSuccinylation, which is among the more recently discovered PTMs, is comparatively unique 3. Like methyla-tion, acetylation or ubiquitination, succinylation also occurs on lysine …
WebOct 8, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair. WebLMSuccSite is likely to serve as a valuable resource for exploration of succinylation and its role in cellular physiology and disease. Protein succinylation is an important post …
WebImproving protein succinylation sites prediction using embeddings from protein language model Protein succinylation is an important post-translational modification (PTM) … WebJan 10, 2024 · The mole fraction of succinylation sites per protein varied from 1 to 23 (Fig. 2c and Supplementary Data 2). Our assessment found 40% (125/314) of proteins with one succinylated site, 20% (60/314 ...
WebZhao X, Ning Q, Chai H, Ma Z, Accurate in silico identification of protein succinylation sites using an iterative semi-supervised learning technique, J Theor Biol 374 ... Pranit LS et al., …
WebJun 27, 2013 · After removing overlapping sites, we identified a total of 2,565 Lys succinylation sites from 779 proteins in mouse cells ( Figures 1 B and 1C). We found that some proteins were highly succinylated, including CPS1 with 47 sites and hydroxyacyl-coenzyme A dehydrogenase (HADHA) with 32 sites ( Figure 1 C and Tables S1 A–S1B). photography alphabet projectWebNov 23, 2024 · The increase of protein succinylation in zebrafish appeared to be larger in response to sucla2 deficiency than with loss of sirt5, confirming what was predicted by … how many words are in teacherWebSuccinylation Links Metabolism to Protein Functions. Post-translational modifications (PTMs) are important regulators of protein function, and integrate metabolism with … photography alphabet challengeWebFeb 1, 2024 · Of all succinylation proteins identified, 48.1% (312/649) possessed only one modified site, 21.4% (139/649) had two succinylated peptide sites, 9.9% (64/649) contained three sites, and 1.2% (8/649) of modified proteins have 10 or more sites (see Figure 1A ). The average degree of succinylation sites per protein was 2.4 (1557/649). photography analysis templateWebJun 23, 2024 · It also verified a strong correlation between gene expression and protein succinylation near the transcriptional start site by showing a correlation between the succinyl-lysine ChIP signal and gene expression, which further indicates that promoter succinylation is a mark of gene transcriptional activity. 27 Recently, it was also found that ... how many words are in the book of proverbsWebIdentifying of post-translational modifications (PTM) is crucial in the study of computational proteomics, cell biology, pathogenesis, and drug development due to its role in many bio-molecular mechanisms. Computational methods for predicting multiple PTM ... photography and art saalfeldWebApr 8, 2024 · LDHA succinylation and protein levels were analysed by immunoblotting using the indicated antibodies. C K1 cells were transfected with HA-LDHA and pCDNA-GLTC (or the empty vector control) for 48 h ... how many words are in italian