Chronopharmacology of glucocorticoids
WebNov 17, 2024 · Chronopharmacology refers to the study of biological rhythm dependencies of drugs to optimize drug therapy by selecting the appropriate time of drug administration, which is associated with maximum efficacy and minimal adverse effects. ... The peripheral clocks have glucocorticoid receptors (GCRs), and its activation can alter the … WebFeb 18, 2024 · In mice with muscle-restricted inducible PGC1α ablation, bioenergetic stimulation by light-phase prednisone required PGC1α. These results demonstrate that glucocorticoid "chronopharmacology" for muscle bioenergetics requires an intact clock and muscle PGC1α activity. Publication types Research Support, N.I.H., Extramural
Chronopharmacology of glucocorticoids
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WebGlucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in homeostasis and preservation of normal organ function. Synthesis is regulated by the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is the primary glucocorticoid … WebJan 10, 2024 · One of the mechanisms through which the central clock entrains peripheral tissues is by the production of glucocorticoids in the adrenal gland. Many other circadian signal transduction mediators also regulate the immune response, as melatonin and the autonomic nervous system (Fig. 1 ).
WebAll these aspects are described herein, providing some insights into the emerging role of chronopharmacology, focusing on glucocorticoid excess and deficiency disorders. Abstract The circadian rhythm derives … WebChronopharmacology of glucocorticoids. Article. Feb 2024; Megerle L. Scherholz; Naomi Schlesinger; Ioannis Androulakis; Glucocorticoids influence a wide array of metabolic, anti-inflammatory ...
WebSci-Hub Chronopharmacology of glucocorticoids. Advanced Drug Delivery Reviews 10.1016/j.addr.2024.02.004 sci hub to open science ↓ save Scherholz, M. L., Schlesinger, N., & Androulakis, I. P. (2024). Chronopharmacology of glucocorticoids. Advanced Drug Delivery Reviews. doi:10.1016/j.addr.2024.02.004 10.1016/j.addr.2024.02.004 versions:
WebFeb 21, 2024 · Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in …
WebGlucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in homeostasis and preservation of normal organ function. Synthesis is regulated by the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is the primary glucocorticoid … chinese food in smithtown nyWebJul 31, 2010 · This article reviews chronotherapy for asthma and the chronopharmacology of drugs developed for administration by new drug delivery systems. The present review also summarizes recent findings concerning the influence of glucocorticoids, β 2 -adrenoceptor agonists, and hypoxia on clock genes. Section snippets Objective … grand lion event center hillview kyWebFeb 18, 2024 · These results demonstrate that glucocorticoid “chronopharmacology” for muscle bioenergetics requires an intact clock and muscle PGC1α activity. … chinese food in smyrna deWebGlucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in … grand lion teaWebSynthetic glucocorticoids are important pharmacological agents that augment the anti-inflammatory Available online 21 February 2024 and immunosuppressive … chinese food in smithfield vaWebSci-Hub Chronopharmacology of glucocorticoids. Advanced Drug Delivery Reviews 10.1016/j.addr.2024.02.004 sci hub to open science ↓ save Scherholz, M. L., … chinese food in smithvilleWebThe chronopharmacology is defined as a branch of chronobiology, which deals with the study of pharmacological characteristics. These studies include the time dependency of … grand lion north vancouver